Diabetes mellitus, znana również jako cukrzyca, jest chorobą hormonalną mającą wiele przyczyn. Dotknięte chorobą koty nie mogą już wydajnie wykorzystywać węglowodanów do produkcji energii, co może skutkować znaczną utratą wagi, a nawet wycieńczeniem. Cukrzycę u kotów można bardzo skutecznie leczyć za pomocą połączenia diety i insulinoterapii.
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